Announcing our newest cancer test. Screen cancer early with Onco-D-clare. Learn more

Clavic-Q-RE_icon
Our Therapies

Clavic-Q-RE

In the evolving landscape of cancer care, immunotherapy is changing cancer treatment forever. We're proud to offer Clavic-Q-RE, a groundbreaking cancer immunotherapy treatment that harnesses the innate power of a patient's own immune system to fight cancer. This autologous approach to personalized cancer care represents the next generation of precision medicine, offering hope to patients seeking alternatives beyond traditional chemotherapy and radiation.

What is Clavic-Q-RE?

Clavic-Q-RE stands as a pioneering immunotherapy treatment for cancer that is a minimally manipulated cellular therapy also known as Autologous Adoptive Cellular Therapy. This innovative therapy is a significant advancement in personalized cancer care, offering patients a targeted approach that works with their body's natural defense mechanisms.

Clavic-Q-RE is classified as a non-modified, autologous use only, adoptive cellular therapy, meaning it uses the patient's own immune cells to create a personalized immunotherapy treatment. This approach removes the burden of immune rejection while maximizing therapeutic effectiveness. The therapy is created exclusively from the patient’s blood, ensuring complete biological compatibility and personalized targeting of the patient’s specific cancer.

The autologous nature of this treatment means that every dose is unique, created from one’s own immune cells and tailored to target the patient’s specific cancer antigens. This personalization is what sets new cancer treatment immunotherapy approaches like Clavic-Q-RE apart from traditional one-size-fits-all treatments.

Clavic-Q-RE contains a comprehensive arsenal of both innate and adaptive immune cells, creating a multi-faceted approach to cancer treatment. The therapy includes:

  • Innate immune cells: Monocytes that turn into macrophages and Natural Killer (NK) cells that provide immediate, broad-spectrum cancer-fighting capability
  • Adaptive immune cells: Activated dendritic cells, cytotoxic T lymphocytes (CTLs), and antibody-producing plasma cells that provide targeted, long-lasting immunity

This combination ensures both immediate and sustained immune response against cancer cells, making it one of the most comprehensive cancer immunotherapy treatments available today.

Clavic-Q-RE monocyte

How Does Clavic-Q-RE Work?

The mechanism of action behind Clavic-Q-RE demonstrates why immunotherapy in cancer treatment has become such a promising field. The therapy works through multiple complementary pathways to identify, target, and eliminate cancer cells throughout the body.

Macrophages & Natural Killer Cells

Macrophages serve as the body's primary cleanup crew, using their phagocytic capabilities to engulf and digest cancer cells and cellular debris. These versatile immune cells can recognize and eliminate cancer cells in an MHC-independent manner, meaning they don't need specific antigen presentation to identify threats.

Natural Killer (NK) cells function as the immune system's rapid response team, capable of immediately recognizing and destroying cancer cells without prior sensitization. They work by detecting abnormal protein expressions on cancer cell surfaces and releasing cytotoxic granules that induce cancer cell death.

Cytotoxic T-cell Activation

The adaptive immune response is orchestrated through dendritic cells. In Clavic-Q-RE, the dendritic cells are already activated in vivo against tumor peptides that are recognized by MHC-II or MHC-I and expressed in the patient’s sample, creating a personalized vaccine effect.

These activated dendritic cells then educate cytotoxic T lymphocytes (CTLs) to recognize and target your specific cancer cells. Once activated, these CTLs circulate throughout the body with the ability to identify and eliminate cancer cells that express the targeted antigens, providing long-lasting, memory-based immunity.

Cancer Cell Tagging

Plasma cells in the therapy have been activated in vivo against specific tumor antigens expressed in the patient’s sample. These antibodies act as molecular "tags," marking cancer cells for destruction by other immune components. This tagging system helps coordinate the immune response and ensures that cancer cells cannot hide from immune surveillance, making it an important tool for immunotherapy in cancer treatment.

Innate Immune Cell + Adaptive Immune Cell Infusions

Clavic-Q-RE is administered as three carefully timed doses, each containing both innate and adaptive immune cells. This staged approach allows for:

  • Immediate response: Innate immune cells provide rapid cancer-fighting activity from the first dose
  • Building immunity: Adaptive immune cells develop and strengthen cancer-specific responses over time
  • Sustained protection: The combination creates both immediate and long-term anti-cancer immunity

The therapy timeline spans four weeks, with doses administered every two weeks, allowing the immune system to build upon each treatment while maintaining therapeutic momentum.

Who is Clavic-Q-RE for?

Understanding patient eligibility is crucial for the success of any immunotherapy treatment for cancer. Clavic-Q-RE has specific indications and considerations that determine its appropriateness for individual patients.

What kind of cancers can be treated with Clavic-Q-RE?

Clavic-Q-RE demonstrates effectiveness against a broad spectrum of malignancies, including:

  • Solid tumors: Including but not limited to breast, lung, prostate, colorectal, pancreatic, kidney, and liver cancers
  • Hematologic cancers: Such as leukemias, lymphomas, and multiple myeloma

The therapy's versatility stems from its ability to target patient-specific cancer antigens, making it adaptable to many different cancer types. The personalized nature of the treatment means it can be tailored to target the unique molecular signature of each patient's cancer.

What kind of cancers will not respond to Clavic-Q-RE?

Currently, Central Nervous System (CNS) cancers are not candidates for Clavic-Q-RE therapy due to the blood-brain barrier. This physiological barrier prevents the therapeutic immune cells from effectively reaching brain tumors, limiting the therapy's effectiveness in treating primary brain cancers and brain metastases.

Get in Touch

At what cancer stage should a patient consider Clavic-Q-RE?


Clavic-Q-RE is appropriate for patients who meet specific staging criteria:

  • Minimum staging: Patients must be staged at grade 2B or higher
  • Treatment-resistant cases: Ideal for patients when conventional treatments have been exhausted
  • Stable disease: The cancer must be stable, not rapidly progressing
  • Other treatments: Patients cannot be receiving concurrent chemotherapy or radiation therapy

This therapy often serves as an excellent option for patients seeking alternatives after conventional treatments have reached their limits, provided their overall health status supports immune-based therapy.

Therapy Details

Understanding the practical aspects of Clavic-Q-RE therapy helps patients prepare for treatment and know what to expect throughout the process.

As an autologous therapy using the patient's own immune cells, Clavic-Q-RE maintains an excellent safety profile. The use of the patient's own cells eliminates the risk of immune rejection and significantly reduces the potential for severe adverse reactions.

The therapy has been extensively studied and refined to minimize risks while maximizing therapeutic benefit. Since the immune cells are derived from a patient's own blood, there is no risk of infectious disease transmission or compatibility issues that might occur with donor-derived therapies.

Before beginning Clavic-Q-RE therapy, patients must complete testing to ensure safety and optimize treatment outcomes:

  • Oncotrace testing: Establishes baseline values for circulating tumor cells, phenotype markers, and stemness markers
  • Immune-Frame analysis: Evaluates immune system status and functionality

These pre-therapy requirements ensure that patients are optimal candidates for immunotherapy and help predict treatment outcomes.

While Clavic-Q-RE maintains an excellent safety profile, patients may experience some reactions as their immune system becomes activated:

  • Flu-like symptoms
  • Fatigue
  • Low-grade fever
  • Injection site reactions (mild skin rash)
  • Urticaria (hives)
  • Pain, swelling, and inflammation at tumor sites (indicating immune activity)

Rare considerations:

  • Tumor Lysis Syndrome (TLS) in patients with large tumor burdens
  • Severe allergic reactions (extremely rare, with no reported cases of life-threatening anaphylaxis)

Most reactions are generally mild and temporary, often indicating that the immune system is responding to the therapy. Patients are closely monitored throughout treatment by their practitioner.

The Clavic-Q-RE treatment protocol follows a carefully designed timeline:

Phase 1: Preparation

  • Pre-therapy testing (Oncotrace and Immune-Frame)
  • Blood collection for therapy preparation
  • Patient counseling and preparation

Phase 2: Treatment

  • Dose 1: Day 0
  • Dose 2: Day 15
  • Dose 3: Day 30

Phase 3: Monitoring

  • 1st Follow-up: Day 120
  • 2nd Follow-up: Day 210

The therapy preparation takes approximately 21 days from blood collection to receipt of the first dose, during which time immune cells which have been activated by the patient’s autologous antigens are selected and isolated.

Two specific tests are mandatory components of the Clavic-Q-RE package:

Oncotrace: This advanced test monitors CTC count, phenotype markers, and stemness markers, providing crucial information about cancer activity and treatment response. The test helps track therapeutic effectiveness and detect early signs of disease progression or remission.

Immune-Frame: This comprehensive immune system analysis evaluates the patient's immune status, including immune cell populations, functionality, and overall immune competence. This testing ensures the patient's immune system can support and benefit from immunotherapy.

These tests are performed both before treatment initiation and after treatment completion to assess therapeutic response and guide ongoing care.

Several factors may preclude patients from receiving Clavic-Q-RE therapy:

  • Current chemotherapy or radiation therapy
  • Recent chemotherapy or radiation
  • Recent blood transfusions
  • Immune suppressant medications
  • Cachexia (severe weight loss and muscle wasting)
  • Pregnancy or breastfeeding
  • Active infections or high inflammation
  • Children under 18 years of age
  • Active autoimmune disease
  • Radioactive seed implants
  • Current Gamma Delta T Cell Therapy (GDTC)

These contraindications exist to ensure patient safety and therapeutic effectiveness. Patients with these conditions may be considered for immunotherapy cancer treatment once the contraindicated condition is resolved or managed.

Patients should consult with their RGCC Practitioner about other potential contraindications.

Clinical Outcomes

The effectiveness of cancer immunotherapy treatments like Clavic-Q-RE continues to be documented through clinical research and patient outcomes. Recent scientific publications demonstrate promising results for this innovative therapy approach.

A peer-reviewed study published in Cancer Letters provides compelling evidence of Clavic-Q-RE's therapeutic potential. The research demonstrates improvement in patient outcomes, including enhanced immune response, tumor reduction, and improved quality of life measures.

The personalized nature of this immunotherapy contributes to its effectiveness, as each treatment is specifically designed to target the individual patient's cancer characteristics and immune profile.

Contact Us to Learn More

Why Choose Clavic-Q-RE?

In the rapidly evolving field where immunotherapy is changing cancer treatment forever, Clavic-Q-RE offers clear advantages that set it apart from other treatment options:

Personalized Approach: Every dose is created specifically from your immune cells and targeted to your cancer antigens, ensuring maximum compatibility and effectiveness.

Comprehensive Immune Response: Unlike single-target therapies, Clavic-Q-RE activates multiple immune pathways, creating a robust, multi-faceted attack against cancer cells.

Excellent Safety Profile: As an autologous therapy, the risk of severe adverse reactions is minimized while therapeutic benefits are maximized.

Proven Science: Backed by peer-reviewed research and developed by RGCC's team of internationally recognized scientists and researchers.

Global Accessibility: Available through RGCC's international network of trained practitioners who specialize in personalized cancer care.

Complementary Care: Can be integrated into comprehensive treatment plans, working alongside other therapies when appropriate.

Immunotherapy represents the culmination of decades of research in cancer immunology and personalized medicine, offering hope to patients who need advanced treatment options.

Take the Next Step in Your Cancer Care

Explore how a new cancer treatment immunotherapy like Clavic-Q-RE could benefit your specific situation.

A personalized treatment journey is a source of confidence, knowing you're working with pioneers in cancer immunotherapy who are committed to advancing patient care through scientific innovation.

Don't wait – the future of cancer treatment is here, and it's personal.

Contact RGCC today to discover how Clavic-Q-RE can become part of your fight against cancer.

Get in Touch
The information provided is for general educational purposes and should not replace professional medical advice.

Videos

Explore our curated collection of videos, providing an in-depth look at our innovative solutions and groundbreaking research.

  • Dr Clayton Bell video cover
    Dr. Clayton Bell, MD | Gathering 2023 Interview

    In this insightful interview from the 2023 RGCC Gathering, Dr. Clayton Bell shares his journey of integrating RGCC technologies into his practice in the U.S.

    With a background in Functional, Environmental, and Integrative Medicine, Dr. Bell reveals how he uses RGCC’s cutting-edge cancer diagnostics and therapies to support his patients’ healing. Watch the full video to learn more.

    Helena Pohlmann video cover
    Helena Pohlmann | Gathering 2023 Interview

    Helena Pöhlmann who specializes in holistic medicine shares how she utilizes RGCC products in her clinic to best support her patients. Watch the video to learn about her experience at the 2023 RGCC Gathering in Switzerland.

    Jenny Hrbacek, RN | About RGCC Testing

    Cancer survivor and RGCC Practitioner, Jenny Hrbaceck, discusses RGCC testing and the impact it has made on her life.

  • Bita Badakhshan
    Bita Badakhshan - RGCC Gathering 2023 Interview

    Watch an interview with Dr. Bita Badakhshan, a seasoned practitioner in primary family medicine with over 12 years of experience in integrative oncology and functional medicine.

    In this video, Dr. Bita shares her experience with RGCC’s transformative liquid biopsy testing. She highlights the unparalleled precision and detail offered by RGCC's advanced methodologies over other laboratories.

    Dr. Bita emphasizes the unmatched sensitivity of RGCC's testing, which delves deep into analyzing stem cells, cancer cells, and a comprehensive array of markers crucial for personalized cancer care.

    Since 2012, Dr. Beta has trusted RGCC for blood testing on patients, particularly focusing on circulating tumor cell analysis and using RGCC’s Oncocount and Oncotrace tests along with the Onconomics Plus assessments.

    Through RGCC's innovative tests and therapies, Dr. Bita has been able to make informed decisions sparing many patients from unnecessary chemotherapy and radiation post-tumor removal surgeries.

    Podcast video cover
    Podcast - Innovation in Early Cancer Detection

    Join host Sam Tejada for an essential conversation about cancer innovation and breakthroughs on this episode of A Healthy Point of View, including a close look at advances in early cancer detection - as early as stage ZERO.

    Tejada sits down with two leading medical experts: Dr. Christopher Davis, an interventional cardiologist and CMO of Liquivida, and Dr. Ioannis Papasotiriou, MD, PhD, SCym, the founder of RGCC.

    Together, they tackle one of medicine's most complex challenges, sharing cutting-edge insights and breakthrough approaches that could transform how we understand and address cancer care.

Videos

Explore our curated collection of videos, providing an in-depth look at our innovative solutions and groundbreaking research.

  • Dr Clayton Bell video cover
    Dr. Clayton Bell, MD | Gathering 2023 Interview

    In this insightful interview from the 2023 RGCC Gathering, Dr. Clayton Bell shares his journey of integrating RGCC technologies into his practice in the U.S.

    With a background in Functional, Environmental, and Integrative Medicine, Dr. Bell reveals how he uses RGCC’s cutting-edge cancer diagnostics and therapies to support his patients’ healing. Watch the full video to learn more.

  • Helena Pohlmann video cover
    Helena Pohlmann | Gathering 2023 Interview

    Helena Pöhlmann who specializes in holistic medicine shares how she utilizes RGCC products in her clinic to best support her patients. Watch the video to learn about her experience at the 2023 RGCC Gathering in Switzerland.

  • Jenny Hrbacek, RN | About RGCC Testing

    Cancer survivor and RGCC Practitioner, Jenny Hrbaceck, discusses RGCC testing and the impact it has made on her life.

  • Bita Badakhshan
    Bita Badakhshan - RGCC Gathering 2023 Interview

    Watch an interview with Dr. Bita Badakhshan, a seasoned practitioner in primary family medicine with over 12 years of experience in integrative oncology and functional medicine.

    In this video, Dr. Bita shares her experience with RGCC’s transformative liquid biopsy testing. She highlights the unparalleled precision and detail offered by RGCC's advanced methodologies over other laboratories.

    Dr. Bita emphasizes the unmatched sensitivity of RGCC's testing, which delves deep into analyzing stem cells, cancer cells, and a comprehensive array of markers crucial for personalized cancer care.

    Since 2012, Dr. Beta has trusted RGCC for blood testing on patients, particularly focusing on circulating tumor cell analysis and using RGCC’s OncoCount and OncoTrace tests along with the Onconomics Plus assessments.

    Through RGCC's innovative tests and therapies, Dr. Bita has been able to make informed decisions sparing many patients from unnecessary chemotherapy and radiation post-tumor removal surgeries.

    Read more about our therapies on our website: https://rgcc-international.com/rgcc-therapies/

    RGCC was launched in 2004 by genetics pioneer Dr. Ioannis Papasotiriou who believes that the key to effectively treating cancer lies in personalized medicine using the information in a patient’s genes.

    Individualized treatment for cancer is the focus behind RGCC’s testing protocols and advanced therapy options. Our slate of tests analyzes the state of a person’s cancer by looking at the cellular and genetic makeup of each patient. Our test results give you information that acts as a blueprint for what treatment protocols are likely to show the most efficacy for your specific biology.

    Learn more about RGCC at
    https://rgcc-international.com/

    Follow us on social media to find out the latest news and updates from our experts.

    Facebook: https://www.facebook.com/profile.php?id=61554630098937

    Instagram: https://www.instagram.com/rgcc_north_america/

    LinkedIn: https://www.linkedin.com/company/r-g-c-c-international-gmbh/

  • Podcast video cover
    Podcast - Innovation in Early Cancer Detection

    Join host Sam Tejada for an essential conversation about cancer innovation and breakthroughs on this episode of A Healthy Point of View, including a close look at advances in early cancer detection - as early as stage ZERO.

    Tejada sits down with two leading medical experts: Dr. Christopher Davis, an interventional cardiologist and CMO of Liquivida, and Dr. Ioannis Papasotiriou, MD, PhD, SCym, the founder of RGCC.

    Together, they tackle one of medicine's most complex challenges, sharing cutting-edge insights and breakthrough approaches that could transform how we understand and address cancer care.

RGCC
Follow Us
RGCC is not liable for any third-party comments or claims regarding our products. For accurate and up-to-date information about our offerings, please refer to our official website: rgcc-international.com
Accreditations
IAS Accreditation
Testing Laboratory
View TL-836 Certificate
EN ISO 22000: 2018
No: 20101200002689
View Certificate
IAS Accreditation
Medical Laboratory
View ML-103 Certificate
ISO 22000: 2018
No: 20101200002689
View Certificate
ISO 45001: 2018
No: 20152220006395
View Certificate
ISO 22716: 2007
No: 20019220006394
View Certificate
CLIA ID Number
99D2283882
View Certificate
College of American Pathologists 
Certificate of Accreditation
CAP#: 9239089 
CLIA#: 99D2283882 
View Certificate
Certificate of GMP Compliance
No. 512863-102689104
View Certificate
Accreditation Certificate of Foreign Cell Processor - Japanese Government
View Certificate
Manufacturing License for Cosmetic Products and Food Supplements under GMP (Good Manufacturing Practices)
Ref. No. 57067
View Details
Hellenic National Organization for Medicines (EOF)
Production License for Investigational ATMPs for Human Use
Ref. No. 7282
View Details
Accreditations
IAS Accreditation
Testing Laboratory
View TL-836 Certificate
EN ISO 22000: 2018
No: 20101200002689
View Certificate
IAS Accreditation
Medical Laboratory
View ML-103 Certificate
ISO 22000: 2018
No: 20101200002689
View Certificate
ISO 45001: 2018
No: 20152220006395
View CertificatePolicy
ISO 22716: 2007
No: 20019220006394
View Certificate
CLIA ID Number
99D2283882
View Certificate
College of American Pathologists 
Certificate of Accreditation
CAP#: 9239089 
CLIA#: 99D2283882 
View Certificate
Certificate of GMP Compliance
No. 512863-102689104
View Certificate
Accreditation Certificate of Foreign Cell Processor - Japanese Government
View Certificate
EOF GMP COSMETICS – SUPPLEMENTS
View Certificate
Call
Text
Email
Map
crosschevron-down