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Our Therapies

Dendritic Cell Therapy

Cancer treatment has seen promising advances in recent years, with immunotherapy emerging as one of the most promising approaches. Among these advances, dendritic cell therapy has gained recognition as a personalized treatment that harnesses the body's natural immune system to fight cancer. This innovative, autologous approach represents a shift away from traditional one-size-fits-all treatments toward precision medicine tailored to individual patients.

What is Dendritic Cell Therapy for Cancer?

Dendritic cells (DCs) are specialized immune cells known as antigen-presenting cells that serve as crucial coordinators of the immune system. These remarkable cells act as key regulators capable of activating T-cells and stimulating the growth and differentiation of B-cells. What makes dendritic cells unique is their ability to identify specific protein markers, called peptides, on the surface of foreign or invading cells.

Once dendritic cells detect these peptide markers, they present them to other immune system cells, essentially teaching them to recognize and target cells that carry these specific markers. This process enables the immune system to seek out and destroy unwanted cells, including cancer cells.
Dendritic cell therapy is an innovative autologous cancer treatment approach that harnesses the natural action of dendritic cells to combat cancer. This therapy works by identifying specific antigens on cancer cells circulating in an individual's blood, enabling the immune system to recognize and destroy these cancer cells throughout the body.

What sets dendritic cell therapy apart from traditional cancer treatments is its personalized approach and gentle mechanism of action. Unlike chemotherapy, dendritic cell therapy is not a genetic therapy and does not involve the use of genotoxic (chemotherapy) drugs. Instead, it works with the body's existing immune system to create a targeted response against cancer cells.

One of the most significant advantages of dendritic cells and cancer therapy is its ability to stimulate memory cells, providing long-lasting immunity against cancer. This means that if the therapy is successful, patients may have ongoing protection against cancer recurrence.
Dendritic cell therapy - Dendritic cell 2

How does Dendritic Cell Therapy work?

Teaching Cells to Recognize Cancer Epitopes

Cancer Epitopes

The primary goal of dendritic cell therapy for cancer is to use dendritic cells to teach T-cells and B-cells to recognize specific cancer epitopes - the unique molecular signatures found on cancer cells. This educational process is fundamental to how dendritic cells and cancer immunotherapy work together.

Immunological Memory

During treatment, dendritic cells activated against specific tumor antigens expressed in patient’s sample are isolated. These activated dendritic cells can in turn effectively communicate this information to CD28 T-cells and CD28 B-cells. These educated immune cells then form immunological memory, which enables them to teach new dendritic cells to execute the same cancer-fighting process.

Long-term Immunity

If dendritic cell therapy is effective, this memory formation provides patients with long-term immunity against their specific cancer cells, potentially preventing recurrence and metastasis.

Who is Dendritic Cell Therapy for?

Cancers Dendritic Cell Therapy Can Treat

Dendritic cell therapy has shown effectiveness in treating solid tumors. This cancer treatment approach can be beneficial for patients with various types of solid cancers, as the therapy can effectively target cancer cells that are accessible through the bloodstream.

The personalized nature of what is dendritic cell therapy for cancer makes it adaptable to different solid tumor types, as this autologous treatment is customized based on the specific antigens present in each patient's cancer cells.

Cancers Dendritic Cell Therapy Cannot Treat

While dendritic cell therapy shows promise for many cancer types, certain cancers may not respond well to this treatment approach:

  • Hematologic malignancies - Blood cancers may not be ideal candidates for this therapy due to their different cellular characteristics and behavior patterns.
  • Testicular cancer - This cancer type has shown limited responsiveness to dendritic cell therapy approaches.
  • Compartmentalized cancers - Cancers that are isolated within specific organs may be more challenging to treat with this systemic approach.
  • Central nervous system (CNS) cancers - These present unique challenges because dendritic cells typically do not cross the blood-brain barrier effectively. While CNS cancers can potentially be treated with dendritic cell therapy, they require tissue biopsy to create the therapy, making the treatment less effective compared to other cancer types.
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Therapy Details

Dendritic cell therapy is generally considered a safe treatment option with minimal side effects. Because the therapy uses the patient's own cells and works with the natural immune system rather than against it, severe reactions are rare.

The safety profile of dendritic cells cancer treatment compares favorably to traditional cancer therapies like chemotherapy and radiation, which often cause significant systemic side effects.

Before beginning dendritic cell therapy, patients must undergo comprehensive evaluation to ensure they are suitable candidates. This includes reviewing medical history, current medications, recent treatments, and overall health status.

Patients should discuss what to avoid prior to therapy with their RGCC practitioner, as certain medications, treatments, or activities may need to be temporarily discontinued or modified.

The dendritic cell therapy protocol consists of three doses administered 21-28 days apart. This spacing allows the immune system time to process and respond to each treatment dose while building cumulative immunity. Following the three-dose series, patients undergo two follow-up tests: the Immune Frame test and Oncotrace test. These follow-up evaluations help assess the therapy's effectiveness and monitor the patient's immune response.

While dendritic cell therapy is generally well-tolerated, some patients may experience mild side effects: 

Common side effects include flu-like symptoms, fatigue, fever, and injection site reactions. These symptoms typically resolve quickly and indicate that the immune system is responding to the therapy. 

Severe reactions are rare due to the personalized nature of the treatment and the use of the patient's own cellular material. 

Patients should promptly report any unusual symptoms to their healthcare practitioner for proper evaluation and management.

Several factors may prevent patients from being eligible for dendritic cell therapy:

  • Recent conventional treatments - Current or recent chemotherapy or radiation therapy can compromise the immune system's ability to respond effectively to dendritic cell therapy.
  • Blood transfusions - Recent blood transfusions may interfere with the therapy's effectiveness.
  • Immune suppression - Patients taking immune suppression medications may not be suitable candidates.
  • Physical condition - Cachexia (severe weight loss and muscle wasting) can indicate that the body may not be strong enough for this treatment approach.
  • Pregnancy and breastfeeding - Safety concerns preclude treatment during pregnancy or while breastfeeding.
  • Age restrictions - Children under 18 are not eligible for this therapy.
  • Autoimmune conditions - Patients with active autoimmune diseases are not eligible due to potential complications.
  • Radioactive treatments - Patients with radioactive seeds are not eligible due to prolonged radiation exposure concerns.
  • Concurrent therapies - Patients receiving Gamma Delta T Cell Therapy (GDTC) are not eligible due to potential interactions.

Patients should consult with their RGCC Practitioner about other potential contraindications.

Clinical Outcomes

Dendritic cell therapy has shown promising results in clinical applications, particularly for patients seeking personalized cancer treatment alternatives. The therapy's ability to create long-lasting immune memory means that successful treatment may provide ongoing protection against cancer recurrence.

Clinical outcomes vary depending on cancer type, stage, patient health status, and individual immune system responsiveness. The personalized nature of dendritic cells and cancer immunotherapy means that each patient's response is unique and based on their specific cancer characteristics.

Success rates are often measured not only by tumor response but also by quality of life improvements, reduced side effects compared to conventional treatments, and enhanced immune system function.

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Why Choose Dendritic Cell Therapy?

Dendritic cell therapy offers several compelling advantages for cancer patients:

Personalized approach - Treatment is customized based on each patient's unique cancer characteristics and immune profile.

Minimal side effects - Unlike chemotherapy, dendritic cell therapy works with the immune system rather than suppressing it.

Long-lasting immunity - Successful therapy can provide ongoing protection against cancer recurrence through immune memory formation.

Non-toxic treatment - The therapy doesn't involve genotoxic drugs or radiation.

Complementary option - Can be used alongside other treatments as part of a comprehensive cancer care plan.

Quality of life - Patients typically experience fewer treatment-related side effects, allowing them to maintain better quality of life during treatment.

The decision to pursue what is dendritic cell therapy for cancer should be made in consultation with qualified practitioners who can assess individual suitability and develop appropriate treatment plans.

taking control of the cancer journey 2

Taking Control of the Cancer Journey

If you're considering dendritic cell therapy as part of a cancer treatment plan, the first step is connecting with an experienced practitioner who specializes in this innovative approach. RGCC's network of trained practitioners can help evaluate whether dendritic cells and cancer therapy might be appropriate for your specific situation.

Every cancer journey is unique, and dendritic cell therapy represents one of the most promising advances in personalized cancer care. By harnessing the body's own immune system, this therapy offers hope for more effective, gentler treatment with the potential for long-lasting protection against cancer recurrence.

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to learn more about how dendritic cell therapy can fit into personalized cancer treatment plans

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The information provided is for general educational purposes and should not replace professional medical advice.

Videos

Explore our curated collection of videos, providing an in-depth look at our innovative solutions and groundbreaking research.

  • Dr Clayton Bell video cover
    Dr. Clayton Bell, MD | Gathering 2023 Interview

    In this insightful interview from the 2023 RGCC Gathering, Dr. Clayton Bell shares his journey of integrating RGCC technologies into his practice in the U.S.

    With a background in Functional, Environmental, and Integrative Medicine, Dr. Bell reveals how he uses RGCC’s cutting-edge cancer diagnostics and therapies to support his patients’ healing. Watch the full video to learn more.

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    Helena Pohlmann | Gathering 2023 Interview

    Helena Pöhlmann who specializes in holistic medicine shares how she utilizes RGCC products in her clinic to best support her patients. Watch the video to learn about her experience at the 2023 RGCC Gathering in Switzerland.

    Jenny Hrbacek, RN | About RGCC Testing

    Cancer survivor and RGCC Practitioner, Jenny Hrbaceck, discusses RGCC testing and the impact it has made on her life.

  • Bita Badakhshan
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    Watch an interview with Dr. Bita Badakhshan, a seasoned practitioner in primary family medicine with over 12 years of experience in integrative oncology and functional medicine.

    In this video, Dr. Bita shares her experience with RGCC’s transformative liquid biopsy testing. She highlights the unparalleled precision and detail offered by RGCC's advanced methodologies over other laboratories.

    Dr. Bita emphasizes the unmatched sensitivity of RGCC's testing, which delves deep into analyzing stem cells, cancer cells, and a comprehensive array of markers crucial for personalized cancer care.

    Since 2012, Dr. Beta has trusted RGCC for blood testing on patients, particularly focusing on circulating tumor cell analysis and using RGCC’s Oncocount and Oncotrace tests along with the Onconomics Plus assessments.

    Through RGCC's innovative tests and therapies, Dr. Bita has been able to make informed decisions sparing many patients from unnecessary chemotherapy and radiation post-tumor removal surgeries.

    Podcast video cover
    Podcast - Innovation in Early Cancer Detection

    Join host Sam Tejada for an essential conversation about cancer innovation and breakthroughs on this episode of A Healthy Point of View, including a close look at advances in early cancer detection - as early as stage ZERO.

    Tejada sits down with two leading medical experts: Dr. Christopher Davis, an interventional cardiologist and CMO of Liquivida, and Dr. Ioannis Papasotiriou, MD, PhD, SCym, the founder of RGCC.

    Together, they tackle one of medicine's most complex challenges, sharing cutting-edge insights and breakthrough approaches that could transform how we understand and address cancer care.

Videos

Explore our curated collection of videos, providing an in-depth look at our innovative solutions and groundbreaking research.

  • Dr Clayton Bell video cover
    Dr. Clayton Bell, MD | Gathering 2023 Interview

    In this insightful interview from the 2023 RGCC Gathering, Dr. Clayton Bell shares his journey of integrating RGCC technologies into his practice in the U.S.

    With a background in Functional, Environmental, and Integrative Medicine, Dr. Bell reveals how he uses RGCC’s cutting-edge cancer diagnostics and therapies to support his patients’ healing. Watch the full video to learn more.

  • Helena Pohlmann video cover
    Helena Pohlmann | Gathering 2023 Interview

    Helena Pöhlmann who specializes in holistic medicine shares how she utilizes RGCC products in her clinic to best support her patients. Watch the video to learn about her experience at the 2023 RGCC Gathering in Switzerland.

  • Jenny Hrbacek, RN | About RGCC Testing

    Cancer survivor and RGCC Practitioner, Jenny Hrbaceck, discusses RGCC testing and the impact it has made on her life.

  • Bita Badakhshan
    Bita Badakhshan - RGCC Gathering 2023 Interview

    Watch an interview with Dr. Bita Badakhshan, a seasoned practitioner in primary family medicine with over 12 years of experience in integrative oncology and functional medicine.

    In this video, Dr. Bita shares her experience with RGCC’s transformative liquid biopsy testing. She highlights the unparalleled precision and detail offered by RGCC's advanced methodologies over other laboratories.

    Dr. Bita emphasizes the unmatched sensitivity of RGCC's testing, which delves deep into analyzing stem cells, cancer cells, and a comprehensive array of markers crucial for personalized cancer care.

    Since 2012, Dr. Beta has trusted RGCC for blood testing on patients, particularly focusing on circulating tumor cell analysis and using RGCC’s OncoCount and OncoTrace tests along with the Onconomics Plus assessments.

    Through RGCC's innovative tests and therapies, Dr. Bita has been able to make informed decisions sparing many patients from unnecessary chemotherapy and radiation post-tumor removal surgeries.

    Read more about our therapies on our website: https://rgcc-international.com/rgcc-therapies/

    RGCC was launched in 2004 by genetics pioneer Dr. Ioannis Papasotiriou who believes that the key to effectively treating cancer lies in personalized medicine using the information in a patient’s genes.

    Individualized treatment for cancer is the focus behind RGCC’s testing protocols and advanced therapy options. Our slate of tests analyzes the state of a person’s cancer by looking at the cellular and genetic makeup of each patient. Our test results give you information that acts as a blueprint for what treatment protocols are likely to show the most efficacy for your specific biology.

    Learn more about RGCC at
    https://rgcc-international.com/

    Follow us on social media to find out the latest news and updates from our experts.

    Facebook: https://www.facebook.com/profile.php?id=61554630098937

    Instagram: https://www.instagram.com/rgcc_north_america/

    LinkedIn: https://www.linkedin.com/company/r-g-c-c-international-gmbh/

  • Podcast video cover
    Podcast - Innovation in Early Cancer Detection

    Join host Sam Tejada for an essential conversation about cancer innovation and breakthroughs on this episode of A Healthy Point of View, including a close look at advances in early cancer detection - as early as stage ZERO.

    Tejada sits down with two leading medical experts: Dr. Christopher Davis, an interventional cardiologist and CMO of Liquivida, and Dr. Ioannis Papasotiriou, MD, PhD, SCym, the founder of RGCC.

    Together, they tackle one of medicine's most complex challenges, sharing cutting-edge insights and breakthrough approaches that could transform how we understand and address cancer care.

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RGCC is not liable for any third-party comments or claims regarding our products. For accurate and up-to-date information about our offerings, please refer to our official website: rgcc-international.com
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Accreditations
IAS Accreditation
Testing Laboratory
View TL-836 Certificate
EN ISO 22000: 2018
No: 20101200002689
View Certificate
IAS Accreditation
Medical Laboratory
View ML-103 Certificate
ISO 22000: 2018
No: 20101200002689
View Certificate
ISO 45001: 2018
No: 20152220006395
View CertificatePolicy
ISO 22716: 2007
No: 20019220006394
View Certificate
CLIA ID Number
99D2283882
View Certificate
College of American Pathologists 
Certificate of Accreditation
CAP#: 9239089 
CLIA#: 99D2283882 
View Certificate
Certificate of GMP Compliance
No. 512863-102689104
View Certificate
Accreditation Certificate of Foreign Cell Processor - Japanese Government
View Certificate
EOF GMP COSMETICS – SUPPLEMENTS
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